China (Mainland)
MonoMethyl auristatin E CAS NO.474645-27-7
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- Min.Order: 1 Kilogram
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- Available Specifications:
99%(1-25)Kilogram99%(1-100)Kilogram99.0%(1-100)Kilogram
- Product Details
Keywords
- MMAE
- High purity Various Specifications Monomethyl Auristatin E CAS:474645-27-7
- CAS:474645-27-7 MMAE
Quick Details
- ProName: MonoMethyl auristatin E
- CasNo: 474645-27-7
- Molecular Formula: C39H67N5O7
- Appearance: Detailed see specifications
- Application: Dolastatin 10 is a natural antimitotic...
- DeliveryTime: Within one week after payment done
- PackAge: According to customer requirements
- Port: Any port of China
- ProductionCapacity: 1 Kilogram/Day
- Purity: 99.0%
- Storage: Store under shade and cool environment...
- Transportation: During the transportation process, all...
- LimitNum: 1 Kilogram
- Moisture Content: ＜0.5%
- Impurity: ＜0.5%
- Assay: ＞99%
Superiority
Hangzhou Benoy Chemical Co., Ltd is a scientific and technological enterprise dedicated to the R & D, production and operation of chemical raw materials, pharmaceutical intermediates and APIs. At present, the company has one R & D center and two production bases. The company has more than 10 full-time personnel engaged in the research and development of APIs and pharmaceutical intermediates, including 2 with doctor's degree, 5 with master's degree, 2 with Professor of Zhejiang University of technology as the chief consultant of the company, with strong scientific research force and rich practical experience. The laboratory is equipped with advanced ultra-high performance liquid chromatography, gas chromatography and relatively complete conventional experimental equipment. Many products have been successfully developed and put into industrial production. The company adheres to the quality and environment policy of "customer first, continuous innovation", and excellent products win good market reputation for the company. At present, the products are exported to Europe, the United States, Southeast Asia and other countries and regions. It is the company's business philosophy to guide technology with information, guarantee quality with technology and win market with quality. The company will give full play to its own advantages and devote itself to the specialization and serialization of pharmaceutical intermediates, so as to provide customers with high-quality, environmental protection and safety products. The company will also be honest, trustworthy, mutually beneficial and co-existence purposes, is willing to sincerely cooperate with customers at home and abroad, hand in hand.
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If you want to find the best price of product, please contact Benoy Chemical.Emial:sales@benoychem.com
Details
| MonoMethyl auristatin E Basic information |
| Product Name: | MonoMethyl auristatin E |
| Synonyms: | MonoMethyl auristatin E(MMAE, vedotin);HM-297C-22;MonoMethyl auristatin E;MMAE;Vedotin;N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide Monomethyl;Monomethyl auristatin E, >=98%;(S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe |
| CAS: | 474645-27-7 |
| MF: | C39H67N5O7 |
| MW: | 717.98 |
| MonoMethyl auristatin E Chemical Properties |
| Boiling point | 873.5±65.0 °C(Predicted) |
| density | 1.088±0.06 g/cm3(Predicted) |
| pka | 13.66±0.20(Predicted) |
| MonoMethyl auristatin E Usage And Synthesis |
| Chemical Properties |
Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer. MMAE is actually desmethyl-auristatin E; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin E itself. |
| Uses | Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.[Cayman Chemical] |