Celecoxib 99% CAS NO.169590-42-5

Hangzhou Benoy Chemical Co., Ltd is a scientific and technological enterprise dedicated to the R & D, production and operation of chemical raw materials, pharmaceutical intermediates and APIs. At present, the company has one R & D center and two production bases. The company has more than 10 full-time personnel engaged in the research and development of APIs and pharmaceutical intermediates, including 2 with doctor's degree, 5 with master's degree, 2 with Professor of Zhejiang University of technology as the chief consultant of the company, with strong scientific research force and rich practical experience. The laboratory is equipped with advanced ultra-high performance liquid chromatography, gas chromatography and relatively complete conventional experimental equipment. Many products have been successfully developed and put into industrial production. The company adheres to the quality and environment policy of "customer first, continuous innovation", and excellent products win good market reputation for the company. At present, the products are exported to Europe, the United States, Southeast Asia and other countries and regions. It is the company's business philosophy to guide technology with information, guarantee quality with technology and win market with quality. The company will give full play to its own advantages and devote itself to the specialization and serialization of pharmaceutical intermediates, so as to provide customers with high-quality, environmental protection and safety products. The company will also be honest, trustworthy, mutually beneficial and co-existence purposes, is willing to sincerely cooperate with customers at home and abroad, hand in hand.

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Celecoxib is a selective COX-2 inhibitor with an IC50 of 40 nM in SF9 cells.

The target COX-2(SF9 cells) was 40 nM

In vitro studies

In vitro, Celecoxib selectively inhibited COX-2 with an IC50 of 40 nM, compared with IC50 of COX-1

15 microns.Celecoxib acts on nasopharyngeal carcinoma (NPC) cell lines, including HNE1 and CNE1-LMP1, and is antiproliferative

The IC50 values were 32.86 μm and 61.31 μm, respectively.

In vivo study

In vivo, Celecoxib has potent oral anti-inflammatory activity.Celecoxib reduces acute inflammation in carrageenan edema detection

In the adjuvant arthritis model, the ED50 was 7.1 mg/kg and 0.37 mg/kg/day respectively.

In addition, Celecoxib also showed analgesic activity in Hargreaves pain model with ED50 of 34.5 mg/kg.this

In addition, Celecoxib was treated with 200 mg/kg dose of Celecoxib and 600 mg/kg dose of Celecoxib per day without acute GI toxicity